Yes, disabling Pulse and Pipewire fixes a lot of problems, I'd done that for years to allow Kodi to see my AV Receiver as a soundcard. However, I lose browser audio.
But I think I found a solution, after running Strawberry, using:
systemctl restart --user pipewire
And I get back audio on the Opera browser.
I just saw you mentioned pipewire-pulse, but I guess you are using PipeWire without PulseAudio then.
My experience has not been great with pipewire either, when openSUSE first came with Pipewire, it was installed automatically without my knowledge, I had a similar or identical issue, the browser stopped working when I had my hw:0,0 setup in Strawberry. I did some testing back then, and found that PipeWire was wasn't working at all without PulseAudio (or at least not with hw), removing PipeWire fixed the issue for me. I always lock pipewire and pulseaudio packages so they can't be installed even after a distro update. I don't know if PipeWire have fixed the issue or not.